Dithiol-based modification of poly(dopamine): enabling protein resistance via short-chain ethylene oxide oligomers.

نویسندگان

  • Amit Vaish
  • David J Vanderah
  • Lee J Richter
  • Michael Dimitriou
  • Kristen L Steffens
  • Marlon L Walker
چکیده

We present a facile strategy to modify poly(dopamine) (PDA)-coated substrates. Using thiol-terminated short chain ethylene oxide oligomers (OEG) under aqueous conditions, we explore the creation of a model surface exhibiting resistance to nonspecific protein absorption (RPA) by engineering the surface properties of a PDA adlayer. Surprisingly, dithiol-terminated OEG molecules demonstrated significantly greater coverage on PDA surfaces than analogous monothiol molecules. Successful RPA is only achieved with dithiol-terminated OEGs.

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عنوان ژورنال:
  • Chemical communications

دوره 51 30  شماره 

صفحات  -

تاریخ انتشار 2015